Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199934 | 0.87 | KDM4E (0.71) | RETFLT3RAF1EGFRKDM4E | |
| SCHEMBL13234464 | 0.84 | RAF1 (0.62) | FLT3RAF1ROCK1RAB9ANPC1 | |
| SCHEMBL13234653 | 0.82 | RAF1 (0.58) | RETFLT3RAF1ROCK1RAB9A | |
| SCHEMBL13200166 | 0.81 | FLT3 (0.55) | RETFLT3RAF1KDM4EROCK1 | |
| SCHEMBL13200527 | 0.80 | FLT3 (0.60) | RETFLT3EGFRROCK1RAB9A | |
| SCHEMBL13200555 | 0.80 | FLT3 (0.73) | RETFLT3RAF1EGFRROCK1 | |
| SCHEMBL13234565 | 0.79 | RAF1 (0.73) | FLT3RAF1RAB9ANPC1MAPK13 | |
| SCHEMBL13200476 | 0.79 | FLT3 (0.65) | RETFLT3RAF1EGFRKDM4E | |
| SCHEMBL13234431 | 0.79 | RAF1 (0.78) | RETFLT3RAF1RAB9ANPC1 | |
| SCHEMBL5784227 | 0.78 | RAF1 (0.56) | RETFLT3RAF1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |