Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234788 | 0.90 | RAF1 (0.68) | FLT3RAF1MAPTKMT2AKDM4E | |
| SCHEMBL13199988 | 0.81 | RET (0.62) | FLT3RAF1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13199934 | 0.80 | KDM4E (0.71) | FLT3RAF1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12066000 | 0.80 | FLT3 (0.57) | FLT3RAF1KDM4ERET | |
| SCHEMBL13200037 | 0.78 | FLT3 (0.73) | FLT3RAF1KMT2AALDH1A1ROCK1 | |
| SCHEMBL13200440 | 0.77 | RAF1 (0.52) | FLT3RAF1MAPTKMT2ACYP2C19 | |
| SCHEMBL13200590 | 0.77 | FLT3 (0.62) | FLT3RAF1MAPTKMT2ANPSR1 | |
| SCHEMBL13200042 | 0.77 | FLT3 (0.62) | FLT3RAF1KMT2AROCK1MEN1 | |
| SCHEMBL13200432 | 0.77 | RAF1 (0.58) | FLT3RAF1KMT2AMEN1MAPK13 | |
| SCHEMBL13200522 | 0.76 | FLT3 (0.69) | FLT3KMT2AROCK1MEN1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |