Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.45 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468928 | 0.78 | FAAH (0.48) | MEN1KMT2APSMB1PSMB8PSMB9 | |
| SCHEMBL13199988 | 0.78 | RET (0.62) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5784425 | 0.75 | EGFR (0.46) | RAF1MAPK13MAPK14RETFLT3 | |
| SCHEMBL1846790 | 0.75 | RAF1 (0.72) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4063019 | 0.73 | PSMB5 (0.49) | PSMB1PSMB8PSMB9PSMB5PSMB10 | |
| SCHEMBL101749 | 0.73 | RAF1 (0.64) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200555 | 0.72 | FLT3 (0.73) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13815845 | 0.72 | RAF1 (0.72) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200476 | 0.72 | FLT3 (0.65) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5573447 | 0.71 | RAF1 (1.00) | RAF1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636220-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | claimed |
| WO-2004099200-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-11-18 | — | — | WO | claimed |
| EP-1636220-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004099200-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-11-18 | — | — | WO | disclosed |