Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 9/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199933 | 0.91 | GAPDH (0.71) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL13234889 | 0.88 | RAF1 (0.65) | FLT3KDRRAF1GAACSF1R | |
| SCHEMBL13200615 | 0.86 | FLT3 (0.62) | FLT3GAPDHRETNTRK1RAF1 | |
| SCHEMBL13199991 | 0.81 | GAPDH (0.58) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL13200780 | 0.81 | FLT3 (0.63) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL1256800 | 0.80 | FLT3 (0.62) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL9978507 | 0.80 | FLT3 (0.62) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL13200383 | 0.79 | RET (0.62) | FLT3GAPDHRETROCK1NTRK1 | |
| SCHEMBL13200004 | 0.79 | FLT3 (0.64) | FLT3RETROCK1NTRK1EGFR | |
| SCHEMBL13200179 | 0.78 | FLT3 (0.53) | FLT3GAPDHRETROCK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |