Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 4/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200526 | 0.85 | RAF1 (0.67) | NPC1RAB9AFLT3RAF1MAPK13 | |
| SCHEMBL13199998 | 0.85 | FLT3 (0.48) | MAPTSMN1; SMN2NPC1RAB9AFLT3 | |
| SCHEMBL13199940 | 0.84 | FLT3 (0.65) | MAPTNPC1RAB9AFLT3RAF1 | |
| SCHEMBL13200008 | 0.84 | FLT3 (0.46) | MAPTPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13199994 | 0.83 | FLT3 (0.47) | SMN1; SMN2NPC1RAB9AFLT3RAF1 | |
| SCHEMBL13199938 | 0.83 | FLT3 (0.55) | MAPTSMN1; SMN2NPC1RAB9AFLT3 | |
| SCHEMBL13200014 | 0.82 | FLT3 (0.53) | MAPTSMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL13200627 | 0.82 | FLT3 (0.48) | MAPTSMN1; SMN2NPC1RAB9AFLT3 | |
| SCHEMBL13234576 | 0.81 | RAB9A (0.72) | MAPTSMN1; SMN2NPC1RAB9AFLT3 | |
| SCHEMBL13199947 | 0.81 | FLT3 (0.53) | SMN1; SMN2NPC1RAB9AHPGDFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |