Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200010 | 0.90 | RET (0.52) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200540 | 0.90 | MAPK14 (0.54) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13199991 | 0.89 | GAPDH (0.58) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200476 | 0.89 | FLT3 (0.65) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200534 | 0.88 | RET (0.53) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13234549 | 0.87 | RAF1 (0.60) | FLT3 | |
| SCHEMBL13200015 | 0.84 | FLT3 (0.57) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200018 | 0.84 | FLT3 (0.56) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200003 | 0.82 | MRGPRX4 (0.54) | RETFLT3ROCK1NTRK1KDM4E | |
| SCHEMBL13200637 | 0.82 | FLT3 (0.54) | RETFLT3ROCK1NTRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |