Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 6/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200476 | 0.93 | FLT3 (0.65) | FLT3ROCK1RETNTRK1RAB9A | |
| SCHEMBL13234558 | 0.87 | RAF1 (0.66) | FLT3RAB9ARAF1MAPK13MAPK12 | |
| SCHEMBL13199991 | 0.87 | GAPDH (0.58) | FLT3ROCK1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13200018 | 0.86 | FLT3 (0.56) | FLT3ROCK1RETNTRK1RAF1 | |
| SCHEMBL13200540 | 0.86 | MAPK14 (0.54) | FLT3ROCK1ALDH1A1SMN1; SMN2RET | |
| SCHEMBL13200534 | 0.86 | RET (0.53) | FLT3ROCK1HTTRETNTRK1 | |
| SCHEMBL13200003 | 0.85 | MRGPRX4 (0.54) | FLT3ROCK1SMN1; SMN2RETNTRK1 | |
| SCHEMBL13234781 | 0.85 | FLT3 (0.81) | FLT3RETRAB9ARAF1MAPK13 | |
| SCHEMBL13200005 | 0.84 | RET (0.52) | FLT3ROCK1RETNTRK1KDM4E | |
| SCHEMBL13200010 | 0.84 | RET (0.52) | FLT3ROCK1RETNTRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |