Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200540 | 0.91 | MAPK14 (0.54) | ALDH1A1MAPK14RETLMNASMN1; SMN2 | |
| SCHEMBL13234582 | 0.87 | MAPK14 (0.73) | MAPK14RETFLT3NPC1RAB9A | |
| SCHEMBL13200145 | 0.86 | RAF1 (0.53) | MAPK14RETFLT3ROCK1NTRK1 | |
| SCHEMBL13200123 | 0.84 | FLT3 (0.53) | MAPK14RETFLT3ROCK1NTRK1 | |
| SCHEMBL13199997 | 0.82 | CNR1 (0.53) | MAPK14RETFLT3ROCK1NTRK1 | |
| SCHEMBL13199934 | 0.82 | KDM4E (0.71) | ALDH1A1RETSMN1; SMN2FLT3ROCK1 | |
| SCHEMBL13199991 | 0.81 | GAPDH (0.58) | ALDH1A1RETSMN1; SMN2FLT3ROCK1 | |
| SCHEMBL13200476 | 0.81 | FLT3 (0.65) | MAPK14RETFLT3ROCK1NTRK1 | |
| SCHEMBL13200620 | 0.81 | FLT3 (0.54) | MAPK14RETFLT3ROCK1NTRK1 | |
| SCHEMBL13200010 | 0.80 | RET (0.52) | RETFLT3ROCK1NTRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |