Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 9/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949523 | 0.86 | RAF1 (0.70) | RAF1RETMAPK13MAPK14RIPK2 | |
| SCHEMBL13200112 | 0.86 | ALDH1A1 (0.54) | RETMAPK14FLT3ROCK1NTRK1 | |
| SCHEMBL13239632 | 0.85 | RAF1 (0.69) | RAF1RETMAPK13MAPK14RIPK2 | |
| SCHEMBL13200123 | 0.82 | FLT3 (0.53) | RAF1RETMAPK13MAPK14FLT3 | |
| SCHEMBL13200111 | 0.82 | FLT3 (0.58) | RAF1MAPK13MAPK14RIPK2FLT3 | |
| SCHEMBL13200081 | 0.81 | TBXAS1 (0.57) | RETFLT3 | |
| SCHEMBL13234580 | 0.81 | RAF1 (0.72) | RAF1RETMAPK13MAPK14RIPK2 | |
| SCHEMBL13199934 | 0.81 | KDM4E (0.71) | RAF1RETFLT3ROCK1NTRK1 | |
| SCHEMBL13200476 | 0.79 | FLT3 (0.65) | RAF1RETMAPK13MAPK14FLT3 | |
| SCHEMBL13199991 | 0.79 | GAPDH (0.58) | RETFLT3ROCK1NTRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |