Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.81 |
| ▸ | KDR | P35968 | 10/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234663 | 0.90 | BRAF (1.00) | BRAFKDREGFRRAF1FLT3 | |
| SCHEMBL13200389 | 0.86 | BRAF (0.77) | BRAFKDRAURKBAURKAEGFR | |
| SCHEMBL4821285 | 0.85 | BRAF (0.71) | BRAFKDREGFRMAPK14RAF1 | |
| SCHEMBL8933899 | 0.80 | AURKB (0.94) | KDRAURKBAURKAEGFRMAPK14 | |
| Hydrochloric Acid SCHEMBL8807597 | 0.79 | AURKB (0.92) | KDRAURKBAURKAEGFRMAPK14 | |
| Anilinoquinazoline1 SCHEMBL1066538 | 0.79 | AURKB (1.00) | KDRAURKBAURKAEGFRMAPK14 | |
| Anilinoquinazoline1 SCHEMBL30195580 | 0.79 | AURKB (1.00) | KDRAURKBAURKAEGFRMAPK14 | |
| Anilinoquinazoline1 SCHEMBL3968007 | 0.78 | AURKB (0.98) | KDRAURKBAURKAEGFRMAPK14 | |
| SCHEMBL5473733 | 0.78 | KDR (0.74) | KDRAURKBAURKAEGFRFLT3 | |
| SCHEMBL5569469 | 0.77 | KDR (0.72) | KDRAURKBAURKAEGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |