Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 1.00 |
| ▸ | KDR | P35968 | 8/20 | 0.68 |
| ▸ | RAF1 | P04049 | 4/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200399 | 0.90 | BRAF (0.81) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL13200389 | 0.87 | BRAF (0.77) | BRAFKDRFLT3EGFR | |
| SCHEMBL2941737 | 0.85 | BRAF (0.74) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL4821285 | 0.82 | BRAF (0.71) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL31067650 | 0.82 | KDR (0.83) | BRAFKDREGFRKIT | |
| SCHEMBL31067666 | 0.82 | KDR (1.00) | BRAFKDREGFRKIT | |
| SCHEMBL31067640 | 0.82 | KDR (0.84) | BRAFKDRFLT3EGFRKIT | |
| SCHEMBL20434902 | 0.81 | FLT3 (1.00) | BRAFRAF1FLT3 | |
| SCHEMBL1780247 | 0.81 | BRAF (1.00) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL1010864 | 0.81 | BRAF (1.00) | BRAFKDRRAF1FLT3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | BRAF 191/4885KDR 1094/4885RAF1 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.