Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.71 |
| ▸ | KDR | P35968 | 10/20 | 0.66 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200399 | 0.85 | BRAF (0.81) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL4548803 | 0.84 | KDR (0.78) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL2747131 | 0.84 | KDR (0.74) | KDREGFRMAPK14 | |
| SCHEMBL2747187 | 0.82 | KDR (0.71) | KDREGFRMAPK14 | |
| SCHEMBL13234663 | 0.82 | BRAF (1.00) | BRAFKDRRAF1FLT3EGFR | |
| SCHEMBL2747980 | 0.81 | EGFR (0.68) | KDRRAF1EGFRMAPK14SRC | |
| SCHEMBL2746962 | 0.81 | KDR (0.62) | KDRFLT3EGFRMAPK14SRC | |
| SCHEMBL2746015 | 0.81 | KDR (0.62) | KDREGFRMAPK14SRC | |
| SCHEMBL4548651 | 0.80 | KDR (1.00) | BRAFKDR | |
| SCHEMBL13200389 | 0.79 | BRAF (0.77) | BRAFKDRFLT3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20060241115-A1 | Compounds and methods of use | AMGEN INC. | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241115-A1 | Compounds and methods of use | HGF, HGFAC, MET | BRAF 170/4885KDR 354/4885RAF1 1183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.