Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234740 | 0.91 | FLT3 (0.58) | FLT3RETMEN1NPC1RAB9A | |
| SCHEMBL13234792 | 0.81 | FLT3 (0.59) | FLT3RETMEN1NPC1RAB9A | |
| SCHEMBL13200037 | 0.78 | FLT3 (0.73) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200093 | 0.78 | FLT3 (0.66) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200219 | 0.77 | FLT3 (0.64) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200580 | 0.76 | FLT3 (0.72) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200025 | 0.76 | FLT3 (0.60) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200153 | 0.76 | FLT3 (0.58) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200052 | 0.76 | FLT3 (0.75) | FLT3ROCK1RETMEN1NPC1 | |
| SCHEMBL13200555 | 0.75 | FLT3 (0.73) | FLT3ROCK1RETMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |