Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 7/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234747 | 0.88 | MEN1 (0.77) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200602 | 0.85 | FLT3 (0.77) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200580 | 0.85 | FLT3 (0.72) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200037 | 0.85 | FLT3 (0.73) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234705 | 0.84 | FLT3 (1.00) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200555 | 0.83 | FLT3 (0.73) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200522 | 0.83 | FLT3 (0.69) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234708 | 0.83 | FLT3 (0.88) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200435 | 0.81 | FLT3 (0.66) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200052 | 0.80 | FLT3 (0.75) | FLT3MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |