Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234756 | 0.91 | FLT3 (0.70) | FLT3RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL13200418 | 0.81 | FLT3 (0.73) | FLT3RAB9ANPC1ROCK1RET | |
| SCHEMBL13200602 | 0.81 | FLT3 (0.77) | FLT3RAB9ANPC1MAPTROCK1 | |
| SCHEMBL13200037 | 0.80 | FLT3 (0.73) | FLT3RAB9ASMN1; SMN2NPC1ROCK1 | |
| SCHEMBL13234705 | 0.80 | FLT3 (1.00) | FLT3RAB9ANPC1RETMEN1 | |
| SCHEMBL13234708 | 0.78 | FLT3 (0.88) | FLT3RAB9ANPC1ROCK1RET | |
| SCHEMBL13200555 | 0.78 | FLT3 (0.73) | FLT3RAB9ANPC1MAPTROCK1 | |
| SCHEMBL13200522 | 0.78 | FLT3 (0.69) | FLT3RAB9ANPC1ROCK1RET | |
| SCHEMBL13200580 | 0.78 | FLT3 (0.72) | FLT3RAB9ANPC1ROCK1RET | |
| SCHEMBL30474858 | 0.78 | SMN1; SMN2 (0.80) | RAB9ASMN1; SMN2NPC1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |