Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200182 | 0.85 | FLT3 (0.50) | FLT3NPC1RAB9ARAF1RET | |
| SCHEMBL13200599 | 0.85 | FLT3 (0.57) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13199940 | 0.84 | FLT3 (0.65) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13200022 | 0.84 | FLT3 (0.56) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13200197 | 0.84 | FLT3 (0.70) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13200028 | 0.82 | FLT3 (0.51) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13234698 | 0.82 | FLT3 (1.00) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13200085 | 0.81 | FLT3 (0.51) | FLT3RAF1CSF1RRETPDGFRB | |
| SCHEMBL13200526 | 0.81 | RAF1 (0.67) | FLT3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL13200027 | 0.80 | FLT3 (0.53) | FLT3KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |