Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 10/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | GAPDH | P04406 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200259 | 0.92 | LMNA (0.54) | FLT3CSF1RRETNTRK1ROCK1 | |
| SCHEMBL13234875 | 0.89 | FLT3 (0.66) | FLT3CSF1RRETNPC1RAB9A | |
| SCHEMBL13200615 | 0.83 | FLT3 (0.62) | FLT3CSF1RRETNTRK1GAPDH | |
| SCHEMBL13234814 | 0.81 | FLT3 (0.61) | FLT3CSF1RRETNPC1RAB9A | |
| SCHEMBL13199933 | 0.81 | GAPDH (0.71) | FLT3RETNTRK1ROCK1GAPDH | |
| SCHEMBL13234683 | 0.81 | FLT3 (0.67) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL13200140 | 0.79 | FLT3 (0.60) | FLT3CSF1RRETNTRK1ROCK1 | |
| SCHEMBL13200373 | 0.79 | FLT3 (0.58) | FLT3CSF1RRETNTRK1ROCK1 | |
| SCHEMBL13200179 | 0.79 | FLT3 (0.53) | FLT3CSF1RRETNTRK1ROCK1 | |
| SCHEMBL13200052 | 0.79 | FLT3 (0.75) | FLT3CSF1RRETNTRK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |