Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.70 |
| ▸ | RELA | Q04206 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CTSA | P10619 | 2/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1131467 | 0.83 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL945400 | 0.81 | RAB9A (0.73) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL5090202 | 0.80 | HDAC3 (0.63) | SMN1; SMN2POLBCTSAIMPDH2HTT | |
| SCHEMBL5093623 | 0.79 | CTSA (0.58) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL4729283 | 0.78 | ALDH1A1 (0.63) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL5090088 | 0.78 | RAB9A (0.62) | RAB9ASMN1; SMN2CTSANPC1ALDH1A1 | |
| SCHEMBL1016413 | 0.77 | MGAM (0.58) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL4534378 | 0.77 | RAB9A (0.71) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL25110541 | 0.77 | MAPT (0.51) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL5093535 | 0.77 | CTSA (0.59) | CTSAALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |