Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834279 | 0.82 | RAB9A (0.73) | EGFRLCKRAB9ANPC1KDM4E | |
| SCHEMBL21200145 | 0.81 | EGFR (0.52) | EGFRLCKKDM4EPOLBCSF1R | |
| SCHEMBL14224554 | 0.81 | EGFR (0.52) | EGFRLCKRAB9ANPC1KDM4E | |
| SCHEMBL29866618 | 0.81 | CBLB (0.64) | EGFRCBLBMEN1KMT2A | |
| SCHEMBL21200143 | 0.81 | CBLB (0.64) | EGFRCBLBMEN1KMT2A | |
| SCHEMBL14876092 | 0.81 | EGLN1 (0.57) | EGFRCSF1RRETPDGFRBKIT | |
| SCHEMBL1205195 | 0.80 | EGFR (0.51) | EGFRLCKRAB9ANPC1KDM4E | |
| SCHEMBL11988788 | 0.80 | EGFR (0.50) | EGFRRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL213288 | 0.79 | EGLN1 (0.60) | EGFRALDH1A1CSF1RRETPDGFRB | |
| SCHEMBL14883271 | 0.79 | EGLN1 (0.56) | EGFRRAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |