Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12978160 | 0.86 | LMNA (0.64) | NPC1RAB9ATRPV1LMNASMN1; SMN2 | |
| SCHEMBL3230527 | 0.85 | CXCR2 (0.63) | ALDH1A1NPC1RAB9AP4HTMPTPN1 | |
| SCHEMBL259419 | 0.85 | MEN1 (0.71) | ALDH1A1NPC1RAB9AKCNK3TSHR | |
| SCHEMBL3643298 | 0.84 | P4HTM (0.65) | ALDH1A1NPC1RAB9AP4HTMKCNK3 | |
| SCHEMBL15651405 | 0.82 | AURKA (0.51) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL3635599 | 0.81 | P4HTM (0.50) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL6686328 | 0.80 | ALDH1A1 (0.71) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL3211467 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL30834320 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL13210581 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4ENPC1RAB9AP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |