Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | SCN4A | P35499 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13196701 | 1.00 | DRD2 (0.41) | DRD2DRD3SIGMAR1HTR2CACHE | |
| SCHEMBL2803299 | 1.00 | DRD2 (0.41) | DRD2DRD3SIGMAR1HTR2CACHE | |
| SCHEMBL6318835 | 0.88 | DRD2 (0.43) | DRD2DRD3SIGMAR1FUCA1 | |
| SCHEMBL13201302 | 0.78 | ACHE (0.44) | DRD2DRD3ACHEBCHEBACE1 | |
| SCHEMBL2801063 | 0.78 | ACHE (0.44) | DRD2DRD3ACHEBCHEBACE1 | |
| SCHEMBL13196676 | 0.78 | ACHE (0.44) | DRD2DRD3ACHEBCHEBACE1 | |
| SCHEMBL5811952 | 0.77 | DRD2 (0.42) | DRD2DRD3SIGMAR1FUCA1 | |
| SCHEMBL705179 | 0.76 | FUCA1 (0.47) | DRD2DRD3SIGMAR1FUCA1SCN4A | |
| SCHEMBL6309643 | 0.74 | DRD2 (0.47) | DRD2DRD3ACHEFUCA1BCHE | |
| SCHEMBL12181407 | 0.74 | ACHE (0.44) | DRD2DRD3SIGMAR1ACHEFUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197724-A1 | 6.5 -PYRROLOPIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | BAO JIANMING | 2010-08-05 | — | — | US | disclosed |
| WO-2009002770-A1 | 6.5-PYRROLOPIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197724-A1 | 6.5 -PYRROLOPIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | TACR1, TACR2, HTR1D | DRD2 75/4885DRD3 135/4885SIGMAR1 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.