Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.45 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18821251 | 0.88 | GAA (0.44) | OPRM1KMT2AL3MBTL1MEN1PPIA | |
| SCHEMBL18821267 | 0.88 | GAA (0.44) | OPRM1KMT2AL3MBTL1MEN1PPIA | |
| SCHEMBL24187768 | 0.88 | GAA (0.44) | OPRM1KMT2AL3MBTL1MEN1PPIA | |
| SCHEMBL13201418 | 0.84 | NPFFR1 (0.44) | ATMNPFFR1NPFFR2KMT2AL3MBTL1 | |
| SCHEMBL18821108 | 0.81 | PPIA (0.43) | OPRM1KMT2AMEN1PPIAHDAC1 | |
| SCHEMBL7396414 | 0.81 | OPRM1 (0.46) | OPRD1OPRM1ATML3MBTL1PPIA | |
| SCHEMBL82429 | 0.80 | KMT2A (0.43) | OPRM1ATMNPFFR1NPFFR2KMT2A | |
| SCHEMBL7396882 | 0.79 | OPRM1 (0.46) | OPRD1OPRM1ATMKMT2AMEN1 | |
| SCHEMBL1997960 | 0.77 | NPFFR1 (0.58) | NPFFR1NPFFR2KMT2AL3MBTL1MEN1 | |
| SCHEMBL24187775 | 0.76 | GAA (0.48) | ATMKMT2AMEN1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |