Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201400 | 0.84 | OPRD1 (0.49) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL27475666 | 0.78 | PPIA (0.52) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL6703813 | 0.76 | NPFFR1 (0.61) | NPFFR1NPFFR2KMT2AL3MBTL1CYP2D6 | |
| SCHEMBL82429 | 0.76 | KMT2A (0.43) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL8087931 | 0.75 | PPIA (0.51) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL13738215 | 0.74 | NPFFR1 (0.57) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL8915173 | 0.74 | PPIA (0.50) | NPFFR1NPFFR2PPIAKMT2AL3MBTL1 | |
| SCHEMBL17608805 | 0.74 | HDAC1 (0.55) | KMT2AMEN1CTSSCTSKCTSB | |
| SCHEMBL1997960 | 0.73 | NPFFR1 (0.58) | NPFFR1NPFFR2KMT2AL3MBTL1MEN1 | |
| SCHEMBL24187768 | 0.72 | GAA (0.44) | PPIAKMT2AL3MBTL1MEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |