Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 6/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259717 | 1.00 | MIF (0.52) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL8126152 | 1.00 | MIF (0.52) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL8125280 | 1.00 | MIF (0.52) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL1962036 | 1.00 | MIF (0.52) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL1962034 | 1.00 | MIF (0.52) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL22832244 | 0.85 | MIF (0.42) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL13696288 | 0.85 | MIF (0.42) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL11128185 | 0.83 | MIF (0.50) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL11128186 | 0.83 | MIF (0.50) | MIFCA1CA2KMT2AMEN1 | |
| SCHEMBL1959830 | 0.83 | MEN1 (0.50) | MIFKMT2AMEN1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |