SCHEMBL13201552

SCHEMBL13201552

c1cn(Cc2ccc(Cn3ccnn3)cc2)nn1

nearest known ligand 0.80

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 13/20 0.80
HTR1A P08908 1/20 0.44
CCR1 P32246 3/20 0.40
CCR2 P41597 3/20 0.40
CCR4 P51679 2/20 0.40
IDO1 P14902 1/20 0.39
TDO2 P48775 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29820095 0.92 CYP19A1 (0.69) CYP19A1CCR1CCR2CCR4IDO1
SCHEMBL4564456 0.92 CYP19A1 (0.69) CYP19A1HTR1AIDO1TDO2
SCHEMBL29820189 0.90 CYP19A1 (0.67) CYP19A1HTR1ACCR1CCR2CCR4
SCHEMBL3153071 0.90 CYP19A1 (0.67) CYP19A1HTR1A
SCHEMBL16129814 0.90 CYP19A1 (0.67) CYP19A1HTR1A
SCHEMBL10194241 0.90 CYP19A1 (0.67) CYP19A1HTR1AIDO1
SCHEMBL6881194 0.90 CYP19A1 (0.67) CYP19A1HTR1ACCR1CCR2CCR4
SCHEMBL155247 0.89 CYP19A1 (1.00) CYP19A1CCR1CCR2
Hydrochloric Acid SCHEMBL7263772 0.87 CYP19A1 (0.96) CYP19A1CCR1CCR2
SCHEMBL31286294 0.87 CYP19A1 (0.62) CYP19A1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7772358-B2 Polytriazoles constructed by 1,3-dipolar cycloaddition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2010-08-10 US disclosed
US-20080103273-A1 Polytriazoles constructed by 1, 3-dipolar cycloaddition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2008-05-01 US disclosed
US-20080103273-A1 Polytriazoles constructed by 1, 3-dipolar cycloaddition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2008-05-01 US disclosed