Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DBH | P09172 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201552 | 0.92 | CYP19A1 (0.80) | CYP19A1HTR1AIDO1TDO2 | |
| SCHEMBL29820095 | 0.84 | CYP19A1 (0.69) | CYP19A1CYP3A4IDO1 | |
| SCHEMBL3153071 | 0.82 | CYP19A1 (0.67) | CYP19A1HTR1AALDH1A1CYP3A4TSHR | |
| SCHEMBL10194241 | 0.82 | CYP19A1 (0.67) | CYP19A1HTR1AALDH1A1IDO1 | |
| SCHEMBL29820189 | 0.82 | CYP19A1 (0.67) | CYP19A1HTR1AALDH1A1TSHRIDO1 | |
| SCHEMBL16129814 | 0.82 | CYP19A1 (0.67) | CYP19A1HTR1A | |
| SCHEMBL6881194 | 0.82 | CYP19A1 (0.67) | CYP19A1HTR1AIDO1TDO2 | |
| SCHEMBL155247 | 0.82 | CYP19A1 (1.00) | CYP19A1CYP1A2POLBCYP3A4 | |
| SCHEMBL27927514 | 0.80 | CYP19A1 (0.64) | CYP19A1ALDH1A1POLB | |
| SCHEMBL4557447 | 0.80 | CYP19A1 (0.46) | CYP19A1HTR1AALDH1A1CYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101333196-B | 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors | STERIX LTD | 2012-06-27 | — | — | CN | disclosed |
| CN-100473648-C | Sulfamate-containing 1,2, 4-triazole derivatives as aromatase inhibitors | STERIX LTD (GB) | 2009-04-01 | — | — | CN | disclosed |
| EP-2010495-A2 | NEW HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | Mutabilis SA (FR) | 2009-01-07 | — | — | EP | disclosed |
| CN-101333196-A | 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors | STERIX LTD (GB) | 2008-12-31 | — | — | CN | disclosed |
| WO-2007135562-A2 | HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS S.A. (FR) | 2007-11-29 | — | — | WO | disclosed |
| CN-1599728-A | Sulfamate-containing 1,2, 4-triazole derivatives as aromatase inhibitors | STERIX LTD (GB) | 2005-03-23 | — | — | CN | disclosed |