Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220949 | 0.86 | PDK2 (0.34) | PAK4 | |
| SCHEMBL13203545 | 0.78 | KDM4E (0.59) | KDM4EMAPTHTTLMNATDP1 | |
| SCHEMBL13221363 | 0.74 | TEK (0.34) | KDM4EMAPTHTTNPC1RAB9A | |
| SCHEMBL13203541 | 0.68 | HDAC6 (0.56) | KDM4EMAPTHTTAPLNR | |
| SCHEMBL22244600 | 0.65 | APLNR (0.60) | RAB9AAPLNR | |
| SCHEMBL13221011 | 0.64 | HDAC6 (0.56) | — | |
| SCHEMBL20021990 | 0.63 | RAB9A (0.63) | NPC1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL13221020 | 0.62 | CSNK1A1 (0.39) | KDM4EHTTRAB9AALDH1A1TDP1 | |
| SCHEMBL2964659 | 0.62 | HDAC6 (0.60) | — | |
| SCHEMBL13203549 | 0.61 | HDAC6 (0.53) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |