Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.64 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320535 | 1.00 | HDAC6 (0.64) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL362072 | 0.85 | ESR1 (0.61) | TNFRSF1ASNCA | |
| SCHEMBL8269262 | 0.84 | HDAC1 (0.56) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL1319893 | 0.81 | SNCA (0.63) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL1319897 | 0.81 | SNCA (0.63) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL6465257 | 0.81 | HDAC4 (0.74) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL14244403 | 0.81 | HSD11B1 (0.67) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL12426309 | 0.81 | HSD11B1 (0.67) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL6882499 | 0.78 | HDAC4 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL1322603 | 0.78 | TNFRSF1A (0.61) | HDAC6HDAC1HDAC3HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814850-B9 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2015-02-25 | — | — | EP | claimed |
| EP-1814850-B1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2013-07-03 | — | — | EP | claimed |
| US-8058273-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2011-11-15 | — | — | US | claimed |
| US-7803800-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2010-09-28 | — | — | US | claimed |
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2010-09-23 | — | — | US | claimed |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | GENEXTRA S.P.A. (IT) | 2008-04-24 | — | — | US | claimed |
| EP-1814850-B9 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2015-02-25 | — | — | EP | disclosed |
| EP-1814850-B1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2013-07-03 | — | — | EP | disclosed |
| US-8058273-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2011-11-15 | — | — | US | disclosed |
| US-7803800-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2010-09-28 | — | — | US | disclosed |
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2010-09-23 | — | — | US | disclosed |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | GENEXTRA S.P.A. (IT) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | HDAC1, HDAC3, HDAC11 | HDAC6 10/4885HDAC1 1/4885HDAC3 2/4885 |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC11 | HDAC6 11/4885HDAC1 1/4885HDAC3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.