Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474231 | 0.91 | MET (0.44) | METTNK2RETNQO2 | |
| SCHEMBL3098728 | 0.88 | MET (0.48) | METTNK2RETHPGDSFGFR1 | |
| SCHEMBL1320797 | 0.87 | MET (0.51) | METTNK2RETHPGDSFGFR3 | |
| SCHEMBL1318277 | 0.86 | MAP4K3 (0.47) | METNQO2 | |
| SCHEMBL13152207 | 0.85 | MET (0.55) | MET | |
| Hydrochloric Acid SCHEMBL1317215 | 0.85 | MAP4K3 (0.46) | MET | |
| SCHEMBL1321592 | 0.82 | MET (0.52) | METTNK2RETHPGDSFGFR1 | |
| SCHEMBL12547684 | 0.81 | MET (0.52) | METTNK2RETHPGDSFGFR1 | |
| SCHEMBL15431645 | 0.81 | MET (0.51) | METTNK2RETHPGDSFGFR1 | |
| SCHEMBL13089764 | 0.79 | MET (0.49) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| EP-2373644-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010078910-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | MET 1/4885TNK2 677/4885RET 2/4885 |
| US-20110269765-A1 | Pyridazinone derivatives | MET, RET, ERBB2 | MET 1/4885TNK2 677/4885RET 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.