Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320728 | 0.91 | MET (0.47) | METNQO2TNK2RET | |
| SCHEMBL1581181 | 0.88 | MET (0.47) | METNQO2 | |
| SCHEMBL2481596 | 0.88 | MET (0.49) | MET | |
| SCHEMBL1318277 | 0.85 | MAP4K3 (0.47) | METNQO2PAK1 | |
| Hydrochloric Acid SCHEMBL1317215 | 0.84 | MAP4K3 (0.46) | METPAK1 | |
| SCHEMBL2479647 | 0.82 | MAP3K7 (0.45) | METRETAXLMERTKPAK1 | |
| SCHEMBL3634219 | 0.79 | MET (0.52) | MET | |
| SCHEMBL3098728 | 0.78 | MET (0.48) | METNQO2TNK2RET | |
| SCHEMBL1320797 | 0.78 | MET (0.51) | METTNK2RET | |
| SCHEMBL13152207 | 0.76 | MET (0.55) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373644-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2373644-A1 | PYRIDAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078910-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |