Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 18/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 17/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13208087 | 0.94 | CXCR2 (0.49) | CXCR2CXCR1 | |
| SCHEMBL13208116 | 0.91 | CXCR2 (0.45) | CXCR2CXCR1 | |
| SCHEMBL14210705 | 0.88 | ALDH1A1 (0.37) | CXCR2CXCR1MAPTTHRB | |
| SCHEMBL13208108 | 0.88 | CXCR2 (0.47) | CXCR2CXCR1 | |
| SCHEMBL13208994 | 0.88 | CXCR2 (0.61) | CXCR2CXCR1MAPTTHRB | |
| SCHEMBL13208067 | 0.85 | CXCR1 (0.53) | CXCR2CXCR1 | |
| SCHEMBL13208089 | 0.85 | CXCR1 (0.46) | CXCR2CXCR1 | |
| SCHEMBL13208027 | 0.84 | CXCR1 (0.55) | CXCR2CXCR1 | |
| SCHEMBL13207062 | 0.81 | CXCR2 (0.48) | CXCR2CXCR1 | |
| SCHEMBL13208965 | 0.81 | CXCR2 (0.62) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786149-B2 | Thiadiazoles as CXC- and CC- chemokine receptor ligands | SCHERING CORP. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786149-B2 | Thiadiazoles as CXC- and CC- chemokine receptor ligands | SCHERING CORP. (US) | 2010-08-31 | — | — | US | disclosed |