Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 4/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13208111 | 0.90 | ALDH1A1 (0.37) | ALDH1A1CNR2CXCR2CXCR1SMN1; SMN2 | |
| SCHEMBL13208108 | 0.89 | CXCR2 (0.47) | CXCR2CXCR1 | |
| SCHEMBL13208113 | 0.88 | CXCR2 (0.48) | CXCR2CXCR1MAPTTHRB | |
| SCHEMBL13208116 | 0.85 | CXCR2 (0.45) | ALDH1A1CXCR2CXCR1SMN1; SMN2 | |
| SCHEMBL13208086 | 0.83 | CXCR2 (0.38) | ALDH1A1CNR2CXCR2CXCR1MAPT | |
| SCHEMBL13207062 | 0.83 | CXCR2 (0.48) | CXCR2CXCR1 | |
| SCHEMBL13208087 | 0.81 | CXCR2 (0.49) | CXCR2CXCR1 | |
| SCHEMBL13208117 | 0.80 | CXCR2 (0.55) | CXCR2CXCR1GAA | |
| SCHEMBL13208089 | 0.79 | CXCR1 (0.46) | CXCR2CXCR1 | |
| SCHEMBL13207053 | 0.78 | CXCR2 (0.47) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090823-A1 | THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | MERCK SHARP & DOHME CORP. | 2008-04-17 | — | — | US | disclosed |
| US-20080090823-A1 | THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | MERCK SHARP & DOHME CORP. | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090823-A1 | THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | CCR2, ACKR3, CX3CR1 | ALDH1A1 500/4885CNR2 41/4885CXCR2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.