Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320085 | 0.93 | AKT1 (0.42) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL1318629 | 0.81 | AKT1 (0.53) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL7682045 | 0.80 | CDK2 (0.43) | USP7AKT1AKT2CDK2CDK4 | |
| SCHEMBL1320290 | 0.79 | CSNK1D (0.42) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL7679500 | 0.79 | CDK2 (0.43) | USP7AKT1AKT2CDK2CDK4 | |
| SCHEMBL1322118 | 0.78 | PIK3CD (0.41) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL1319308 | 0.78 | ABL1 (0.41) | CDK2CDK4CCNE1RAB9AKDM4E | |
| SCHEMBL7676761 | 0.77 | AKT1 (0.51) | USP7AKT1AKT2TRPM8NPC1 | |
| SCHEMBL7676827 | 0.77 | ABCC9 (0.38) | USP7AKT1AKT2CDK2CDK4 | |
| SCHEMBL1321698 | 0.76 | KCNQ3 (0.44) | USP7PIK3CDPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058274-B2 | Heterocycles as potassium channel modulators | ICAGEN, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| WO-2011102964-A1 | HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2011-08-25 | — | — | WO | disclosed |