Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 8/20 | 0.69 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13890982 | 0.86 | ACKR3 (0.77) | ACKR3TNFRSF1AALDH1A1AKR1C2 | |
| SCHEMBL3614587 | 0.83 | ACKR3 (0.83) | ACKR3TNFRSF1A | |
| SCHEMBL3614590 | 0.83 | ACKR3 (0.83) | ACKR3TNFRSF1A | |
| SCHEMBL3539267 | 0.82 | ACKR3 (1.00) | ACKR3TNFRSF1AALDH1A1KDM4E | |
| SCHEMBL3539270 | 0.82 | ACKR3 (1.00) | ACKR3TNFRSF1AALDH1A1KDM4E | |
| SCHEMBL14601254 | 0.81 | ACKR3 (0.48) | ACKR3TNFRSF1AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL12410228 | 0.78 | ACKR3 (0.76) | ACKR3 | |
| SCHEMBL3537999 | 0.77 | ACKR3 (0.64) | ACKR3TNFRSF1APOLB | |
| SCHEMBL3537997 | 0.77 | ACKR3 (0.64) | ACKR3TNFRSF1APOLB | |
| SCHEMBL3537236 | 0.77 | ACKR3 (0.75) | ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777009-B2 | Compositions for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. | 2009-02-26 | — | — | US | disclosed |
| US-7253007-B2 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CXCR3, CCR2, CCL2 | ACKR3 7/4885TNFRSF1A 421/4885MAPK1 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.