Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.64 |
| ▸ | CCR1 | P32246 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13226429 | 0.90 | CCR2 (0.67) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13226443 | 0.88 | CCR2 (0.65) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13226327 | 0.87 | CCR2 (0.77) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13253574 | 0.87 | CCR2 (0.77) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL19677882 | 0.87 | CCR2 (0.77) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL14100891 | 0.87 | CCR2 (0.63) | CCR2 | |
| SCHEMBL13226452 | 0.87 | CCR2 (0.71) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13226457 | 0.85 | CCR2 (0.68) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13226455 | 0.85 | CCR2 (0.71) | CCR2KCNH2CCR1TMEM97SIGMAR1 | |
| SCHEMBL13226473 | 0.84 | CCR2 (0.55) | CCR2KCNH2CCR1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786305-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786305-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-1501507-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7230008-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK & CO, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230008-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK & CO, INC. (US) | 2007-06-12 | — | — | US | disclosed |