SCHEMBL19677882

SCHEMBL19677882

CC(C)C1(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)CCC(NC2CCOCC2)C1

nearest known ligand 0.77

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CCR2 P41597 18/20 0.77
▸ CCR1 P32246 1/20 0.77
▸ TMEM97 Q5BJF2 1/20 0.77
▸ SIGMAR1 Q99720 1/20 0.77
▸ KCNH2 Q12809 8/20 0.68
▸ CCR5 P51681 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13253574 1.00 CCR2 (0.77) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226327 1.00 CCR2 (0.77) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226452 0.94 CCR2 (0.71) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226455 0.92 CCR2 (0.71) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226462 0.91 CCR2 (0.66) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226517 0.91 CCR2 (0.68) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226457 0.91 CCR2 (0.68) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226445 0.91 CCR2 (0.69) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226466 0.90 CCR2 (0.66) CCR2CCR1TMEM97SIGMAR1KCNH2
SCHEMBL13226395 0.90 CCR2 (0.84) CCR2CCR1TMEM97SIGMAR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200405889-A1 METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2020-12-31 — — US disclosed
US-20170348442-A1 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2017-12-07 — — US disclosed
US-20170348442-A1 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2017-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170348442-A1 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS CCR2, CCR1, CCR3 CCR2 1/4885CCR1 2/4885TMEM97 449/4885
US-20200405889-A1 METHODS FOR DETECTING CCR2 RECEPTORS CCR2, CCR1, CCR5 CCR2 1/4885CCR1 2/4885TMEM97 422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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