SCHEMBL1322693

SCHEMBL1322693

Fc1c(Cl)c(F)c(C(F)(F)F)c(F)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.36
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7069317 0.88 TSHR (0.33) NOTUMTSHRSMN1; SMN2
SCHEMBL28517192 0.88 NOTUM (0.36) NOTUMTSHRSMN1; SMN2
SCHEMBL11705250 0.82 NOTUM (0.32) NOTUMTSHRSMN1; SMN2
SCHEMBL11705255 0.82 NOTUM (0.32) NOTUM
SCHEMBL11261942 0.81 NOTUM (0.36) NOTUM
SCHEMBL28781590 0.80 NOTUM (0.32) NOTUM
SCHEMBL10697043 0.80 TSHR (0.38) NOTUMTSHRSMN1; SMN2
SCHEMBL9747850 0.80 NOTUM (0.33) NOTUM
SCHEMBL9244075 0.80 NOTUM (0.33) NOTUM
SCHEMBL11267899 0.79 NOTUM (0.34) NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4885415-A HYDROGENATION, DECHLORINATION, CATALYSIS BAYER AKTIENGESELLSCHAFT (DE) 1989-12-05 US claimed
EP-2684932-B1 DIARYLAMINO MATRIX MATERIAL DOPED WITH A MESOMERIC RADIALENE COMPOUND HODOGAYA CHEMICAL CO LTD (JP) 2016-09-28 EP disclosed
EP-2684932-A1 Diarylamino matrix material doped with a mesomeric radialene compound Novaled AG (DE) 2014-01-15 EP disclosed
US-8057712-B2 Radialene compounds and their use NOVALED AG (DE) 2011-11-15 US disclosed
EP-2180029-B1 Radialene compounds and their use NOVALED AG (DE) 2011-07-27 EP disclosed
US-20100102709-A1 RADIALENE COMPOUNDS AND THEIR USE NOVALED AG (DE) 2010-04-29 US disclosed
EP-2180029-A1 Radialene compounds and their use Novaled AG (DE) 2010-04-28 EP disclosed
US-6372774-B1 THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES RHONE-POULENC AGRICULTURE LTD. (GB) 2002-04-16 US disclosed
US-6265627-B1 HEATING HALOGEN-CONTAINING AROMATIC COMPOUNDS WITH AN ALKALI METAL FLUORIDE IN PRESENCE OF N,N'N?-HEXA-SUBSTITUTED GUANIDINIUM HALIDE AS CATALYST TO PRODUCE POLYFLUOROAROMATIC COMPOUND Igumnov, Sergei Mikhailovich (RU) 2001-07-24 US disclosed
US-5916618-A PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT RHONE-POULENC AGRICULTURE LTD. (GB) 1999-06-29 US disclosed
US-4939170-A Substituted aminophenyl carbamates BAYER AKTIENGESELLSCHAFT (DE) 1990-07-03 US disclosed
US-4885415-A HYDROGENATION, DECHLORINATION, CATALYSIS BAYER AKTIENGESELLSCHAFT (DE) 1989-12-05 US disclosed
EP-0339418-A2 Substituted anilides of the cycloalkyl- or heterocyclyl-carboxylic acids BAYER AG (DE) 1989-11-02 EP disclosed
US-4868347-A SOLVENT EXTRACTION BAYER AKTIENGESELLSCHAFT (DE) 1989-09-19 US disclosed
EP-0293718-A2 Substituted aminophenyl carbamate BAYER AG (DE) 1988-12-07 EP disclosed
EP-0270964-A2 Process for obtaining substituted fluorobenzenes BAYER AG (DE) 1988-06-15 EP disclosed
EP-0234119-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1987-09-02 EP disclosed
WO-1987003781-A1 PESTICIDAL METHOD USING N-PHENYLPYRAZOLES MAY & BAKER LIMITED (GB) 1987-07-02 WO disclosed
EP-0023647-B1 Process for the preparation of halogenated benzoyl fluorides BAYER AG (DE) 1982-06-30 EP disclosed
US-4330366-A Process for the preparation of halogenated benzoyl fluorides BAYER AKTIENGESELLSCHAFT (DE) 1982-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100102709-A1 RADIALENE COMPOUNDS AND THEIR USE CHRNB2, CHRNB3, CHRNB4 NOTUM 2165/4885TSHR 4024/4885SMN1; SMN2 3356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.