Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322789 | 1.00 | APP (0.65) | APPAKR1B10AKR1B1ATMHCAR2 | |
| SCHEMBL18608171 | 0.86 | APP (0.65) | APPAKR1B10AKR1B1ATMALOX5 | |
| SCHEMBL27934208 | 0.85 | TTR (0.61) | APPAKR1B10AKR1B1ALOX5 | |
| SCHEMBL4623272 | 0.85 | APP (0.68) | APPAKR1B10AKR1B1ATMHCAR2 | |
| SCHEMBL4623274 | 0.85 | APP (0.68) | APPAKR1B10AKR1B1ATMHCAR2 | |
| SCHEMBL1579811 | 0.85 | TTR (0.61) | APPAKR1B10AKR1B1ALOX5 | |
| SCHEMBL19244390 | 0.85 | APP (0.64) | APPAKR1B10AKR1B1ATM | |
| SCHEMBL8296939 | 0.85 | APP (0.64) | APPAKR1B10AKR1B1ATM | |
| SCHEMBL8296940 | 0.85 | APP (0.64) | APPAKR1B10AKR1B1ATM | |
| SCHEMBL15026294 | 0.85 | APP (0.64) | APPAKR1B10AKR1B1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814850-B9 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2015-02-25 | — | — | EP | disclosed |
| EP-1814850-B1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2013-07-03 | — | — | EP | disclosed |
| US-8058273-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2011-11-15 | — | — | US | disclosed |
| US-7803800-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2010-09-28 | — | — | US | disclosed |
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2010-09-23 | — | — | US | disclosed |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | GENEXTRA S.P.A. (IT) | 2008-04-24 | — | — | US | disclosed |
| EP-1814850-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006037761-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | HDAC1, HDAC3, HDAC11 | APP 4731/4885AKR1B10 550/4885AKR1B1 484/4885 |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC11 | APP 4709/4885AKR1B10 678/4885AKR1B1 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.