Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296939 | 1.00 | APP (0.64) | APPNPSR1AKR1B10AKR1B1ATM | |
| SCHEMBL19637918 | 0.92 | APP (0.62) | APPNPSR1AKR1B10AKR1B1PKM | |
| SCHEMBL31030969 | 0.86 | TTR (0.60) | APPNPSR1AKR1B10AKR1B1PKM | |
| SCHEMBL1177761 | 0.86 | TTR (0.60) | APPNPSR1AKR1B10AKR1B1PKM | |
| SCHEMBL1177764 | 0.86 | TTR (0.60) | APPNPSR1AKR1B10AKR1B1PKM | |
| SCHEMBL18608171 | 0.85 | APP (0.65) | APPAKR1B10AKR1B1ATM | |
| SCHEMBL1322789 | 0.85 | APP (0.65) | APPAKR1B10AKR1B1ATM | |
| SCHEMBL1322790 | 0.85 | APP (0.65) | APPAKR1B10AKR1B1ATM | |
| Hydrochloric Acid SCHEMBL10463632 | 0.85 | TTR (0.58) | APPNPSR1AKR1B10AKR1B1PKM | |
| Hydrochloric Acid SCHEMBL10463631 | 0.85 | TTR (0.58) | APPNPSR1AKR1B10AKR1B1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |