Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
| ▸ | PDE8B | O95263 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10174179 | 0.83 | ADORA2A (0.48) | ADORA2AADORA1ADORA2BPDE8BADORA3 | |
| SCHEMBL13233223 | 0.83 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BPDE8BADORA3 | |
| SCHEMBL13727333 | 0.80 | ADORA2A (0.41) | ADORA2AADORA1ADORA2BPDE8BADORA3 | |
| SCHEMBL20063802 | 0.77 | ADORA3 (0.38) | ADORA2AADORA1ADORA2BADORA3TLR7 | |
| SCHEMBL25515677 | 0.72 | TLR7 (0.56) | ADORA2AADORA1ADORA2BADORA3TLR7 | |
| SCHEMBL14224935 | 0.72 | ADORA2A (0.50) | ADORA2AADORA1ADORA2BPDE8BADORA3 | |
| SCHEMBL13233224 | 0.71 | CDK1 (0.69) | ADORA2AADORA1ADORA2BCDK1CCNB1 | |
| SCHEMBL13091617 | 0.69 | CDK1 (0.38) | ADORA2AADORA1ADORA2BADORA3TLR7 | |
| SCHEMBL31296886 | 0.69 | ADORA2A (0.50) | ADORA2AADORA1ADORA2BPDE8BADORA3 | |
| SCHEMBL5731164 | 0.68 | TLR7 (0.55) | ADORA2AADORA1ADORA2BTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754728-B2 | Adenine compound and use thereof | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |