Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 5/20 | 0.63 |
| ▸ | FLT3 | P36888 | 5/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234453 | 0.86 | MAPK14 (0.64) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL13234432 | 0.85 | RAF1 (0.93) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL21174246 | 0.84 | FLT3 (0.87) | RAF1BRAFFLT3 | |
| Hydrochloric Acid SCHEMBL21174119 | 0.83 | FLT3 (0.85) | RAF1BRAFFLT3 | |
| SCHEMBL13234431 | 0.81 | RAF1 (0.78) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL13234371 | 0.81 | RAF1 (0.86) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL2951112 | 0.81 | RAB9A (0.77) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL13234441 | 0.81 | RAB9A (0.71) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL13234435 | 0.80 | MAPK14 (0.78) | RAF1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL13234666 | 0.80 | MAPK14 (0.78) | RAF1MAPK14MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | RAF1 372/4885MAPK14 1436/4885MEN1 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.