Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | MEN1 | O00255 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945639 | 0.86 | GBA1 (0.65) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL10078887 | 0.84 | MEN1 (1.00) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL14014120 | 0.79 | RAB9A (0.80) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL10078938 | 0.78 | KMT2A (0.65) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL208697 | 0.78 | MEN1 (0.72) | KMT2AMEN1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12585091 | 0.78 | NOX1 (0.73) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21295527 | 0.77 | MEN1 (0.77) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL77442 | 0.77 | KMT2A (0.68) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL22103784 | 0.77 | RAB9A (0.76) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL13234618 | 0.77 | MAPK14 (0.94) | KMT2AMEN1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | KMT2A 285/4885MEN1 4362/4885NPC1 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.