Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.76 |
| ▸ | POLB | P06746 | 4/20 | 0.76 |
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014120 | 0.89 | RAB9A (0.80) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL10078887 | 0.86 | MEN1 (1.00) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL20788543 | 0.85 | NPC1 (0.77) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL20791859 | 0.82 | NPC1 (0.76) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL13234810 | 0.82 | NPC1 (0.69) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL17988256 | 0.82 | RAB9A (1.00) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL22125497 | 0.81 | SMARCA2 (0.72) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL78768 | 0.80 | FFAR2 (0.60) | RAB9ASMN1; SMN2POLBNPC1MEN1 | |
| SCHEMBL21708002 | 0.80 | CCR4 (0.71) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL5459405 | 0.78 | RAB9A (0.62) | RAB9ASMN1; SMN2POLBNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |