Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 7/20 | 0.61 |
| ▸ | BRAF | P15056 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | RAF1 | P04049 | 3/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234896 | 0.87 | NTRK1 (0.54) | NTRK1NTRK3NTRK2RETBRAF | |
| SCHEMBL13200210 | 0.87 | RET (0.74) | NTRK1NTRK3NTRK2RETFLT3 | |
| SCHEMBL13234895 | 0.85 | NTRK1 (0.54) | NTRK1NTRK3NTRK2RETBRAF | |
| SCHEMBL3762933 | 0.82 | NTRK1 (0.61) | NTRK1NTRK3NTRK2RETBRAF | |
| SCHEMBL19646968 | 0.81 | FLT3 (0.72) | NTRK1NTRK3NTRK2RETBRAF | |
| SCHEMBL28514347 | 0.78 | NTRK3 (1.00) | NTRK1NTRK3NTRK2RETBRAF | |
| SCHEMBL1698822 | 0.78 | MAPK14 (0.76) | FLT3KDRRAF1MAPK13MAPK12 | |
| SCHEMBL13234663 | 0.76 | BRAF (1.00) | BRAFFLT3KDRRAF1KIT | |
| SCHEMBL13234368 | 0.76 | MAPK14 (0.72) | RETFLT3KDRRAF1MAPK13 | |
| SCHEMBL13234365 | 0.76 | MAPK14 (0.72) | FLT3KDRRAF1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | NTRK1 3986/4885NTRK3 3209/4885NTRK2 3806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.