Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236365 | 0.83 | RECQL (0.46) | ALDH1A1SMN1; SMN2KDM4EMAPTTSHR | |
| SCHEMBL24642948 | 0.82 | LMNA (0.41) | ALDH1A1SMN1; SMN2KDM4EMAPTTSHR | |
| SCHEMBL30057498 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL23843447 | 0.78 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL3397754 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL2294079 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL2294082 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL21549684 | 0.78 | RECQL (0.31) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2554949 | 0.77 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL28571485 | 0.77 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759357-B2 | Phenylpyrimidine amines as IgE inhibitors | NOVARTIS AG (CH) | 2010-07-20 | — | — | US | disclosed |
| US-7759357-B2 | Phenylpyrimidine amines as IgE inhibitors | NOVARTIS AG (CH) | 2010-07-20 | — | — | US | disclosed |
| US-20070281956-A1 | Phenylpyrimidine amines as IgE inhibitors | NOVARTIS AG (CH) | 2007-12-06 | — | — | US | disclosed |
| US-20070281956-A1 | Phenylpyrimidine amines as IgE inhibitors | NOVARTIS AG (CH) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281956-A1 | Phenylpyrimidine amines as IgE inhibitors | FCER2, SELP, FCGR2A | ALDH1A1 1102/4885SMN1; SMN2 4789/4885KDM4E 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.