Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | KIT | P10721 | 6/20 | 0.50 |
| ▸ | FLT3 | P36888 | 5/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24853341 | 0.86 | PDPK1 (0.53) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL30788040 | 0.86 | PDPK1 (0.53) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL2660889 | 0.82 | GAA (0.56) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL30168107 | 0.81 | KDR (0.48) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL24852599 | 0.81 | KDR (0.48) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL12607759 | 0.80 | CYP1A2 (0.41) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL22349133 | 0.76 | AXL (0.40) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL569660 | 0.76 | GAA (0.61) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL25950681 | 0.75 | BTK (0.43) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL628649 | 0.75 | PDPK1 (0.66) | PDPK1GAAMAP2K1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355125-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-11-18 | — | — | US | disclosed |
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | InventisBio Co., Ltd. (CN) | 2021-08-17 | — | — | US | disclosed |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-07-01 | — | — | US | disclosed |
| WO-2020233592-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | INVENTISBIO SHANGHAI LTD. (CN) | 2020-11-26 | — | — | WO | disclosed |
| US-7759344-B2 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | KRAS, NRAS, HRAS | PDPK1 381/4885GAA 3609/4885MAP2K1 224/4885 |
| US-20210355125-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | KRAS, NRAS, HRAS | PDPK1 273/4885GAA 3548/4885MAP2K1 286/4885 |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | KRAS, NRAS, HRAS | PDPK1 381/4885GAA 3609/4885MAP2K1 224/4885 |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | MET, REL, NAT1 | PDPK1 3931/4885GAA 979/4885MAP2K1 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.