Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 9/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953707 | 0.93 | TPMT (0.53) | TPMTHPGDLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6172498 | 0.92 | TPMT (0.52) | TPMTHPGDLMNAMEN1KMT2A | |
| SCHEMBL6647950 | 0.86 | HPGD (0.42) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23471123 | 0.83 | ALDH1A1 (0.44) | HPGDLMNAGAATSHRALDH1A1 | |
| SCHEMBL14141210 | 0.83 | TP53 (0.50) | TPMTHPGDLMNAMEN1KMT2A | |
| SCHEMBL13306259 | 0.82 | TPMT (0.52) | TPMTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29475792 | 0.81 | HPGD (0.54) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7115213 | 0.81 | MLYCD (0.43) | TPMTHPGDMLYCDBACE1BACE2 | |
| SCHEMBL3195578 | 0.80 | TPMT (0.46) | TPMTHPGDLMNAMEN1KMT2A | |
| SCHEMBL3886133 | 0.80 | MLYCD (0.45) | HPGDSMN1; SMN2ALDH1A1MLYCDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763646-B2 | Compounds for the treatment of alzheimer's disease | ELAN PHARMACEUTICALS, INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7763646-B2 | Compounds for the treatment of alzheimer's disease | ELAN PHARMACEUTICALS, INC. (US) | 2010-07-27 | — | — | US | disclosed |