Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.69 |
| ▸ | RELA | Q04206 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | SCD | O00767 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200871 | 0.84 | CSNK1D (0.77) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL13234642 | 0.83 | POLB (0.61) | ALOX5EPHX2NPC1MAPTRAB9A | |
| SCHEMBL1143751 | 0.83 | NPC1 (1.00) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL21858370 | 0.82 | NPC1 (1.00) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4889787 | 0.82 | HDAC1 (0.57) | ALOX5EPHX2NPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL28640786 | 0.81 | NPC1 (0.97) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL21295527 | 0.80 | MEN1 (0.77) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL32674581 | 0.78 | NPC1 (0.84) | EPHX2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL27634788 | 0.78 | NPC1 (0.84) | EPHX2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL13234641 | 0.78 | MEN1 (0.61) | NPC1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | ALOX5 4302/4885EPHX2 3083/4885NPC1 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.