Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 8/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.77 |
| ▸ | RELA | Q04206 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | WNT3A | P56704 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SCD | O00767 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30050826 | 0.88 | CSNK1D (1.00) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL11585824 | 0.88 | CSNK1D (1.00) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL13200869 | 0.87 | WNT3A (0.64) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL13239642 | 0.84 | ALOX5 (0.70) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL28691084 | 0.83 | MAPK1 (0.67) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL30636141 | 0.83 | MAPK1 (0.67) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL13200845 | 0.82 | POLB (0.63) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL17287636 | 0.81 | CSNK1D (0.80) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL6179039 | 0.80 | NPC1 (0.76) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL17287753 | 0.80 | CSNK1D (1.00) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |