Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.64 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941737 | 0.92 | BRAF (0.74) | BRAFRAF1EGFRKDRMAPK14 | |
| SCHEMBL13234663 | 0.78 | BRAF (1.00) | BRAFRAF1EGFRKDRFLT3 | |
| SCHEMBL1013264 | 0.73 | BRAF (1.00) | BRAFRAF1EGFRKDRMAPK14 | |
| SCHEMBL1013427 | 0.73 | BRAF (0.77) | BRAFRAF1 | |
| SCHEMBL13234895 | 0.73 | NTRK1 (0.54) | BRAFRAF1KDRMAPK14FLT3 | |
| SCHEMBL13234371 | 0.73 | RAF1 (0.86) | BRAFRAF1MAPK14FLT3MEN1 | |
| SCHEMBL13234456 | 0.71 | RAF1 (0.69) | BRAFRAF1MAPK14FLT3MEN1 | |
| SCHEMBL13234432 | 0.71 | RAF1 (0.93) | RAF1MAPK14FLT3MEN1NPC1 | |
| SCHEMBL13853030 | 0.71 | RAF1 (0.74) | RAF1KDRMAPK14FLT3MEN1 | |
| SCHEMBL13234430 | 0.71 | MAPK14 (0.76) | RAF1KDRMAPK14FLT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | BRAF 191/4885RAF1 372/4885EGFR 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.